The nonstop is quickest: American DSM → CLT (2h 30m), on time 4 times in 5. Southwest via Midway (4h 45m) is more reliable, 91%, but takes 2h 15m longer.
Nonstops (seasonal or thin)
Nonstop details →| American | DSM | CLT | 2h 30m | 83% | 3.0% | 809 | Flying now |
Best connections, any airlines
Ranked by chance you reach Charlotte on time. Total trip = scheduled departure to arrival, layover included (Charlotte is 1 h ahead of Des Moines). Layovers up to 4 hours. Pick a connection for the details.
| SouthwestDetails → | DSM 05:10 → MDW 06:30WN 1772 | 1h 20m Chicago | MDW 07:50 → CLT 10:55WN 2749 | 4h 45m | 95% | 91% |
| UnitedDetails → | DSM 06:00 → ORD 07:40UA 1856 | 2h 46m Chicago | ORD 10:26 → CLT 13:50UA 3450 · flown by Republic | 6h 50m | 96% | 83% |
| Southwest + Unitedtwo ticketsDetails → | DSM 06:10 → DEN 07:00WN 1769 | 2h 50m Denver | DEN 09:50 → CLT 15:12UA 1633 | 8h 02m | 90% | 80% |
| AmericanDetails → | DSM 09:02 → ORD 10:44AA 4969 · flown by SkyWest | 2h 33m Chicago | ORD 13:17 → CLT 16:29AA 3280 | 6h 27m | 96% | 80% |
| DeltaDetails → | DSM 05:35 → ATL 08:44DL 2727 | 1h 26m Atlanta | ATL 10:10 → CLT 11:26DL 3190 | 4h 53m | 96% | 80% |
| Delta + Americantwo ticketsDetails → | DSM 06:50 → MSP 08:12DL 5402 · flown by Endeavor | 2h 44m Minneapolis | MSP 10:56 → CLT 14:36AA 2154 | 6h 46m | 91% | 79% |
| DeltaDetails → | DSM 10:54 → MSP 12:06DL 4998 · flown by Endeavor | 3h 09m Minneapolis | MSP 15:15 → CLT 18:49DL 2821 | 6h 53m | 98% | 76% |
| AmericanDetails → | DSM 05:00 → ORD 06:39AA 4519 · flown by Republic | 2h 51m Chicago | ORD 09:30 → CLT 12:38AA 2502 | 6h 38m | 97% | 75% |
| Tight connection: often missed | ||||||
| DeltaDetails → | DSM 18:03 → MSP 19:15DL 5020 · flown by Endeavor | 1h 00m Minneapolis | MSP 20:15 → CLT 23:46DL 2929 | 4h 43m | 74% | 56% |
| DeltaDetails → | DSM 10:25 → DTW 13:13DL 5048 · flown by Endeavor | 52m Detroit | DTW 14:05 → CLT 15:58DL 1429 | 4h 33m | 66% | 56% |
| UnitedDetails → | DSM 15:01 → IAH 17:25UA 6117 · flown by Mesa | 47m Houston | IAH 18:12 → CLT 21:59UA 2864 | 5h 58m | 69% | 52% |
Same layover, different day-part
How often the first flight arrives too late to connect (45 min minimum), for one-ticket layovers of 45–80 minutes.
Delays build through the day, so an afternoon first leg eats the layover. A short connection is fine early in the morning and a gamble later on.
Mixing airlines
The table above includes two-ticket connections (marked “two tickets”), held to the 90-minute minimum. One ticket only →
Regional partners count as the airline that sells them: SkyWest flying Delta Connection is one Delta ticket.
About this data: US DOT on-time records, Aug 2025 – Jul 2026, all US airlines; regional flights count under the airline that sells them. Schedules (which flights and connections exist, and their times) are as of Jun 6 – Jul 31, 2026; seasonal flights outside that window aren’t ranked. Rebuilt monthly. JSON